Serious game is now a multi-billion dollar industry and is still growing steadily in many sectors. As a major subset of serious games, de-signing and developing Virtual Reality (VR), Augmented Reality (AR), and serious games or adopting off-the-shelf games to support medical educa-tion, rehabilitation, or promote health has become a promising frontier in the healthcare sector since 2004, because games technology is inexpensive, widely available, fun and entertaining for people of all ages, with various health conditions and different sensory, motor, and cognitive capabilities. In this chapter, we provide the reader an overview of the book with a perspec-tive of future trends of VR, AR simulation and serious games for health-care.