This chapter explores the philosophical notion of The Virtual in response to the writings of Gilles Deleuze and unfolds this thinking through its interdisciplinary and transformative effects upon contemporary fine art. The Virtual will be discussed in relation to forms of contemporary painting, yet, provides a model for thinking through interdisciplinarity within, and from, other media. The Virtual acts as an instigator for change, which effectively destabilises the pre-formity attached to medium specific practices. It is for this reason that The Virtual forces external relationships and connections to come to the fore in order to radically alter and transform the physical and conceptual constructs of different disciplines. This paper will highlight these important ideas and present new ways to consider The Virtual in relation to contemporary fine art practice, with a particular focus upon current issues in Painting.