The chapter outlines the work of the collective Locus, which was formed to explore architecture through the direct construction of spatial experiments in selected contexts. Locus’s research resides in the context of spatial investigation that architects and artists have engaged in since the early 20th century, a culture of speculation, which explores the basic conceptions of architecture and space. This speculation occurs in a broader dialogue, where scientific thought, popular media and technological change, constantly raise new ideas regarding the relationship between mental and physical realities. The work accepts that spectators may not experience space conscious of the various spatial ideas discussed in the disciplines of art, architecture and science, however these ideas are part of the cultural context in which space is experienced. This research extends this speculation with a methodology that is perceptual, haptic and visceral. The chapter outlines the work produced by Locus with a brief discussion of the relationship between this creative practice and the professional and academic activities of the collaborative participants. The book chapter is titled, Creative Practice, in the book “Creativity”, edited by Johan Verbeke, will be published by KU Leuven, with publication date still pending.