This thesis contributes both to the specific field of MEMS, and also to the broader field of bimanual input within the field of Human Computer Interaction (HCI).  A user survey, contextual and literature review, three user studies and a mock-up MEMS interface, form the argument and development of this work.  The significant empirical findings of this investigation result from the three usability studies that assessed bimanual configurations with nine to eighteen MEMS domain experts and frequent 3D interface users (such as modellers and CAD users). The first speculative user study assessed the broad implications of bimanual 2D and 3D interaction.  The second study investigated the usability of both spatial and constrained hardware input devices within a desktop based bimanual setting.  The third evaluation investigated the device implementation and specifically compared spatial isotonic and isometric with both a constrained method 6 degree of freedom device and 2 degree of freedom mouse based 3D methods. The significant qualitative outcomes illustrate the differences in response between the MEMS domain and 3D interface users.  The quantitative results describe the performance qualities of a range of bimanual implementations of 2D/3D interaction.  Through the presentation of the evaluations and also the research related to bimanual task implementation, this thesis will describe an account of the usability of bimanual 2D/3D interaction systems for the desktop.